Structure-Guided Drug Discovery Consulting
From structural insight to better compound decisions.
Coulombix provides integrated structural biology, SBDD, CADD, and scientific decision support for drug discovery programs.
Our Mission
Turning complex biology and chemistry into better decisions and better compounds.
Why Coulombix
Scientific Judgment
We focus on interpreting structural, computational, and experimental evidence rather than simply generating more data.
Integrated Expertise
Structural biology, SBDD, CADD, simulation, and data-driven approaches are connected around the scientific decision.
Flexible Support
Focused internal expertise can be extended through specialized external partners when experimental or additional capabilities are needed.
What We Do
Scientific expertise focused on actionable decisions
40+ Years of Combined Scientific Experience Across Our Two Co-Founders
Biology Strategy
Protein construct design, expression and purification strategy, CRO coordination, and scientific oversight.
SBDD
Protein crystallization strategy, X-ray structure analysis, binding-mode interpretation, and structure-guided ligand design.
CADD
Molecular docking, virtual screening, molecular dynamics, free-energy analysis, and computational compound optimization.
Decision Support
Integrated scientific assessment, compound prioritization, and actionable recommendations for drug discovery.
Client Outcomes
What Can You Expect from Coulombix?
Explore our services, scientific deliverables, and the value they bring to your discovery program.
What We Provide
Structural feasibility assessment, target and binding-site characterization, druggability evaluation, gene-to-structure consulting, and experimental strategy guidance.
Deliverables
Target and binding-site assessment reports, structure quality evaluations, discovery opportunity maps, scientific risk assessments, and recommended next steps.
Expected Client Value
Clearer discovery direction, reduced scientific uncertainty, and more informed program decisions.
What We Provide
Protein–ligand interaction analysis, experimental and predicted binding-mode interpretation, structure–activity relationship support, and structure-guided compound design.
Deliverables
Binding-mode interpretation reports, annotated interaction maps, structural SAR analyses, and prioritized design hypotheses.
Expected Client Value
Mechanistic insight and actionable structure-guided design direction.
What We Provide
Structure- and ligand-based virtual screening, compound library evaluation, hit triage, chemical clustering, docking, rescoring, and comparative analysis.
Deliverables
Prioritized compound shortlists, chemical diversity analyses, comparative scoring summaries, binding hypotheses, and hit selection recommendations.
Expected Client Value
More focused hit selection, faster compound prioritization, and better-informed experimental decisions.
What We Provide
Structure-guided SAR interpretation, scaffold hopping, bioisosteric replacement, analog design, selectivity assessment, and molecular property evaluation.
Deliverables
Optimization proposals, prioritized analog and scaffold suggestions, SAR and selectivity assessments, molecular property comparisons, and design–make–test recommendations.
Expected Client Value
More focused chemical exploration and better-supported optimization decisions.
What We Provide
Molecular dynamics, conformational analysis, binding interaction dynamics, free-energy calculations, and comparative molecular evaluation.
Deliverables
Molecular simulation analyses, interaction dynamics summaries, comparative energetic assessments, compound rankings with methodological limitations, and mechanistic interpretations.
Expected Client Value
Deeper molecular understanding and stronger evidence for compound evaluation and prioritization.
What We Provide
Molecular visualization, integrated structural and computational data analysis, scientific reporting, reproducible workflow development, and data automation support.
Deliverables
Decision-ready scientific reports, publication-quality figures, integrated analysis summaries, reproducible workflow documentation, and workflow improvement recommendations.
Expected Client Value
Clearer scientific communication, reproducible analyses, and more efficient discovery decisions.
Representative Services
| Service Area | Representative Services | |
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| Structural Biology & SBDD |
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| CADD & Computational Drug Design |
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| Molecular Simulation & Free Energy |
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| Discovery Strategy & Decision Support |
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| AI-Enabled Discovery & Data Intelligence |
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| Discovery Infrastructure & Workflow Automation |
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| Scientific Visualization & Communication |
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| Biophysics & Experimental Validation Strategy |
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Contact
Tell us about your project.
Start a discussion about your target, structural data, computational results, or current scientific decision point.
